🗺️ Best AI tools for Spatial omics (2026)

Tools for spatial transcriptomics and proteomics: deconvolution, domain detection, alignment, histology-to-expression prediction and spatial data frameworks.

13 tools · 13 open source · each entry links to its website, code and paper.

Dated by release date, else first public paper, preprint or release date; undated tools listed after, A–Z.

Language-conditioned model that predicts cell-level spatial gene expression from histology across tissues and gene panels.

Spatial omicsOpen source#histology#spatial-expression

Nicheformer

Foundation model pretrained on dissociated and spatial single-cell data.

Spatial omicsOpen source#foundation-model

moscot

Multi-omics single-cell optimal transport for space and time mapping.

Spatial omicsOpen source#optimal-transport#scverse

SpatialData

Unified data framework for spatial omics technologies.

Spatial omicsOpen source#data-format#scverse

GraphST

Graph self-supervised contrastive learning for spatial transcriptomics.

Spatial omicsOpen source#contrastive#domains

Squidpy

Spatial single-cell analysis toolkit in the scverse ecosystem.

Spatial omicsOpen source#python#neighborhood

STAGATE

Graph attention autoencoder for spatial domain identification.

Spatial omicsOpen source#domains#gnn

PASTE

Optimal-transport alignment and integration of spatial transcriptomics slices.

Spatial omicsOpen source#optimal-transport#alignment

Bayesian mapping of fine-grained cell types in spatial transcriptomics.

Spatial omicsOpen source#deconvolution#bayesian

BayesSpace

Bayesian clustering and resolution enhancement of spatial transcriptomics.

Spatial omicsOpen source#clustering#r

Tangram

Maps single-cell profiles onto spatial data with deep learning.

Spatial omicsOpen source#mapping#deconvolution

Robust cell type decomposition for spatial transcriptomics.

Spatial omicsOpen source#deconvolution#r

Comprehensive R toolbox for spatial data analysis and visualization.

Spatial omicsOpen source#r#visualization