🌀 Best AI tools for RNA structure & design (2026)

RNA secondary and 3D structure prediction, RNA foundation models and RNA design.

8 tools · 8 open source · each entry links to its website, code and paper.

Dated by release date, else first public paper, preprint or release date; undated tools listed after, A–Z.

RhoFold+

RNA language-model-based method for 3D RNA structure prediction.

RNA structure & designOpen source#rna-structure#3d

RibonanzaNet

RNA foundation model trained on Ribonanza chemical-mapping data for structure and reactivity.

RNA structure & designOpen source#rna-structure#chemical-mapping

gRNAde

Geometric deep learning for 3D RNA inverse design (sequence design from backbone).

RNA structure & designOpen source#rna-design#gnn

RNA-FM

RNA foundation model pretrained on 23M non-coding RNAs for structure and function tasks.

RNA structure & designOpen source#foundation-model#ncrna

UFold

Fast image-like U-Net for RNA secondary structure prediction.

RNA structure & designOpen source#secondary-structure#u-net

EternaFold

RNA secondary structure model trained via multitask learning on Eterna player data.

RNA structure & designOpen source#secondary-structure#thermodynamics

SPOT-RNA

Deep learning RNA secondary structure prediction including non-canonical pairs and pseudoknots.

RNA structure & designOpen source#secondary-structure#pseudoknots

ViennaRNA

Standard RNA secondary structure prediction and design package (RNAfold, RNAinverse).

RNA structure & designOpen source#secondary-structure#design