Orthrus
Bo Wang lab's mature-RNA foundation model trained with contrastive learning on splice isoforms and orthologs, for RNA half-life and other property prediction.
| Category | RNA structure & design |
|---|---|
| GitHub | bowang-lab/Orthrus |
| First public | 2024-10-12 (source) |
| Paper | https://www.nature.com/articles/s41592-026-03064-3 · Nature Methods (2026) |
| License | MIT |
| Pricing | Open source |
| Tags | #foundation-model#mrna#contrastive |
| Last checked | 2026-10-16 |
Specs
| Task | RNA property prediction (half-life, localization, function) |
|---|---|
| Structure level (2D / 3D) | Mature mRNA transcripts |
| Input | RNA sequence (+ splice/CDS tracks) |
| GitHub stars | 131 |
| Interface | — |
Specs come from each project's README, paper or official page · Orthrus paper · Orthrus README. “—” means we couldn't verify it.
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