RFdiffusion
Diffusion model for de novo protein backbone design and binder design.
| Category | Protein structure & design |
|---|---|
| GitHub | RosettaCommons/RFdiffusion |
| First public | 2022-12-10 (source) |
| Paper | https://www.nature.com/articles/s41586-023-06415-8 |
| License | BSD-3-Clause |
| Pricing | Open source |
| Tags | #design#diffusion |
| Last checked | 2026-10-16 |
Compare with… RFdiffusion vs BindCraft
Specs
| Task | Backbone generation, binder design, motif scaffolding |
|---|---|
| Modalities | Protein (binders, symmetric assemblies) |
| MSA required | — |
| Open weights | Yes |
| GPU need | — |
| GitHub stars | 3,090 |
| Interface | Package, Docker, Colab |
Specs come from each project's README, paper or official page · RFdiffusion README · RFdiffusion paper. “—” means we couldn't verify it.
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