AlphaFold Server (AlphaFold 3) vs Chai-1

AlphaFold Server (AlphaFold 3): Structure prediction of proteins, nucleic acids, ligands and their complexes; hosted web server plus open code, weights on request for non-commercial use. Chai-1: Multimodal foundation model for molecular structure prediction.

Facts below come from each project's own website, repository and paper. We don't publish benchmark claims here; see the papers for evaluations. Shared tags: structure, complexes.

FieldAlphaFold Server (AlphaFold 3)Chai-1
TaskStructure predictionStructure prediction
ModalitiesProtein, nucleic acid, small molecule, ion, modified residues, complexProtein, nucleotides, ligands (SMILES), modified residues, complex
MSA requiredYes (genetic/template search data pipeline)Optional (single-sequence mode supported)
Open weightsOn request (terms of use)Yes (Apache-2.0); web interface incl. commercial
GPU needGPU required for inference; MSA search is CPU-onlyRequired: CUDA + bfloat16; A100/H100/L40S recommended
LicenseApache-2.0 (code; AlphaFold 3 model parameters terms (non-commercial weights))Apache-2.0
PricingNo cost (research use)Open source
Released2024-05-082024-09-09
PaperLinkLink
GitHubGitHubGitHub
GitHub stars8,6472,003
InterfaceDockerPackage, Docker, Web

License and commercial use

FieldAlphaFold Server (AlphaFold 3)Chai-1
Code licenseApache-2.0Apache-2.0
Weights licenseAlphaFold 3 model parameters terms (non-commercial weights)Apache-2.0
Commercial useMixed (code vs weights differ)Permissive (commercial OK)
AnswerPartly. The code and the weights (or hosted service) are under different terms; the restrictive part does not allow commercial use. DetailsYes. The recorded license is permissive, so closed-source commercial use is allowed if you keep the notices. Details

Add more Protein structure & design tools to this comparison →

More Protein structure & design comparisons

← All Protein structure & design tools