AlphaFold Server (AlphaFold 3) vs Boltz
AlphaFold Server (AlphaFold 3): Structure prediction of proteins, nucleic acids, ligands and their complexes; free web server and code, weights on request for non-commercial use. Boltz: Open biomolecular interaction models (Boltz-1, Boltz-2) for complex structure and binding-affinity prediction.
Facts below come from each project's own website, repository and paper. We don't publish benchmark claims here; see the papers for evaluations. Shared tags: structure.
| Field | AlphaFold Server (AlphaFold 3) | Boltz |
|---|---|---|
| Task | Structure prediction | Structure + binding-affinity prediction |
| Modalities | Protein, nucleic acid, small molecule, ion, modified residues, complex | Biomolecular complexes |
| MSA required | — | Optional (MSA server flag) |
| Open weights | On request (terms of use) | Yes (MIT) |
| GPU need | — | Recommended; CPU supported but much slower |
| License | Apache-2.0 (code); AlphaFold 3 model parameters terms (non-commercial weights) | MIT |
| Pricing | Free (research) | Open source |
| Released | 2024-05-08 | 2024-11-17 |
| Paper | Link | Link |
| GitHub | GitHub | GitHub |
| GitHub stars | 8,646 | 4,255 |
| Interface | Docker | Package |
Specs come from each project's README, paper or official page · AlphaFold Server (AlphaFold 3) README · AlphaFold Server (AlphaFold 3) paper · Boltz README · Boltz paper. “—” means we couldn't verify it.
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