RFdiffusion2
Atom-level enzyme active-site scaffolding with diffusion, no sequence-position constraints.
| Category | Protein structure & design |
|---|---|
| GitHub | RosettaCommons/RFdiffusion2 |
| First public | 2025-04-10 (source) |
| Paper | https://doi.org/10.1038/s41592-025-02975-x |
| License | BSD-3-Clause |
| Pricing | Open source |
| Tags | #enzyme-design#diffusion#all-atom |
| Last checked | 2026-10-16 |
Specs
| Task | Enzyme active-site scaffolding |
|---|---|
| Modalities | Enzyme from functional-group geometry |
| MSA required | — |
| Open weights | Yes |
| GPU need | — |
| GitHub stars | 450 |
| Interface | — |
Specs come from each project's README, paper or official page · RFdiffusion2 README · RFdiffusion2 paper. “—” means we couldn't verify it.
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