Protein2PAM
Profluent's protein language model that predicts a Cas enzyme's PAM specificity from its sequence and guides PAM-engineering of Cas9 variants.
| Category | CRISPR & gene editing |
|---|---|
| GitHub | Profluent-AI/protein2pam |
| First public | 2026-02-02 (source) |
| Paper | https://www.nature.com/articles/s41587-025-02995-0 · Nature Biotechnology (2026) |
| License | PolyForm Noncommercial (code); CC BY-NC 4.0 (weights) |
| Pricing | Open source (non-commercial) |
| Tags | #pam#cas-engineering#protein-language-model |
| Last checked | 2026-10-16 |
Specs
| Editing system | Type I, II and V CRISPR-Cas |
|---|---|
| Task | PAM specificity prediction and Cas variant design |
| Organisms | Any (sequence-based) |
| GitHub stars | 15 |
| Interface | — |
Specs come from each project's README, paper or official page · Protein2PAM paper · Protein2PAM README. “—” means we couldn't verify it.
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