← CRISPR & gene editing

OpenCRISPR-1

AI-designed Cas9-like gene editor from Profluent's language models, released openly.

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CategoryCRISPR & gene editing
GitHubProfluent-AI/OpenCRISPR
First public2024-04-22 (source)
Paperhttps://doi.org/10.1038/s41586-025-09298-z
LicenseProfluent OpenCRISPR license (free, incl. commercial)
PricingOpen source
Tags#generative#gene-editor#protein-lm
Last checked2026-10-16

Specs

Editing systemCas9-like (Type II), NGG PAM
TaskAI-designed gene editor
OrganismsHuman cells (demonstrated)
GitHub stars1,209
Interface—

Specs come from each project's README, paper or official page · OpenCRISPR-1 README · OpenCRISPR-1 paper. “—” means we couldn't verify it.

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