OptiPrime
David Liu lab's mechanistic ML model that predicts prime-editing efficiency and outcomes for PE2, PE3 and twinPE, with a web server.
| Category | CRISPR & gene editing |
|---|---|
| GitHub | alvin-hsu/optiprime-src |
| First public | 2026-02-20 (source) |
| Paper | https://www.nature.com/articles/s41587-026-03261-7 · Nature Biotechnology (2026) |
| License | no license file in repo |
| Pricing | Free (research) |
| Tags | #prime-editing#guide-design#web-server |
| Last checked | 2026-10-16 |
Specs
| Editing system | Prime editing (PE2, PE3, twinPE) |
|---|---|
| Task | pegRNA efficiency and outcome prediction |
| Organisms | Human and mouse cells |
| GitHub stars | 6 |
| Interface | — |
Specs come from each project's README, paper or official page · OptiPrime paper · OptiPrime README. “—” means we couldn't verify it.
Compare with…
Pick 1–3 other CRISPR & gene editing tools to compare side by side with OptiPrime.
Related
AI-designed Cas9-like gene editor from Profluent's language models, released openly.
CRISPR & gene editingOpen source#generative#gene-editor
Analysis of genome-editing outcomes from amplicon sequencing, including base and prime editing.
CRISPR & gene editingOpen source (non-commercial)#editing-outcomes#amplicon
LLM agent that plans and automates gene-editing experiments: system selection, guide design, protocols and analysis.
CRISPR & gene editingResearch release#agent#llm