GPN-Star
Phylogeny-aware genomic language model over whole-genome alignments and species trees for genome-wide variant effect and constraint prediction.
| Category | Genomics & DNA models |
|---|---|
| GitHub | songlab-cal/gpn |
| First public | 2025-09-21 (source) |
| Paper | https://doi.org/10.1038/s41586-026-11005-5 · Nature (2026) |
| Code license | MIT |
| Weights license | Hugging Face checkpoints MIT |
| What this allows | Permissive (commercial OK) Use, modify and ship it inside closed-source commercial products; keep the license text and copyright notices. What do these mean? |
| License source | huggingface.co/songlab/gpn-star-hg38-v100-200m · checked 2026-10-20 |
| Pricing | Open source |
| Tags | #variant-effect#dna-lm#alignment#evolution |
| Last checked | · links verified |
Can I use GPN-Star commercially?
Yes. The recorded license is permissive, so closed-source commercial use is allowed if you keep the notices.
- Code: MIT
- Weights: Hugging Face checkpoints MIT
- Source: huggingface.co/songlab/gpn-star-hg38-v100-200m · license checked 2026-10-20
What the license types mean · not legal advice.
Specs
| Input length / context | — |
|---|---|
| Resolution | — |
| Species | Human (vertebrate, mammal, primate alignments) plus mouse, chicken, fly, worm, Arabidopsis |
| Tasks | Coding and non-coding variant effect prediction, constraint scores |
| GitHub stars | 385 |
| Interface | Package (pip install gpn), CLI, precomputed scores |
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