AlphaDIA vs DIA-NN
AlphaDIA: DIA proteomics search engine without feature detection, with transfer learning from AlphaPeptDeep. DIA-NN: Neural-network-powered data-independent acquisition (DIA) proteomics processing software.
Facts below come from each project's own website, repository and paper. We don't publish benchmark claims here; see the papers for evaluations. Shared tags: dia, mass-spec.
| Field | AlphaDIA | DIA-NN |
|---|---|---|
| Acquisition (DDA / DIA) | DIA | DIA |
| Task | Search engine (empirical or predicted libraries) | Identification + quantification |
| Input | Thermo .raw, Bruker .d, others | — |
| License | Apache-2.0 | Proprietary (no cost for academic use) |
| Pricing | Open source | No cost (research use) |
| Released | 2023-02-24 | 2018-03-15 |
| Paper | Link | Link |
| GitHub | GitHub | GitHub |
| GitHub stars | 118 | 488 |
| Interface | Package, Docker | Docker |
License and commercial use
| Field | AlphaDIA | DIA-NN |
|---|---|---|
| Code license | Apache-2.0 | Proprietary (no cost for academic use) |
| Weights license | — | — |
| Commercial use | Permissive (commercial OK) | Non-commercial |
| Answer | Yes. The recorded license is permissive, so closed-source commercial use is allowed if you keep the notices. Details | No. The recorded terms do not allow commercial use without a separate license from the owner. Details |
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