ESMFold2 & ESMC (Biohub)
Biohub's protein 'world model': ESMC language model (~2.8B sequences), ESMFold2 complex structure prediction/design, and ESM Atlas (6.8B sequences).
| Category | Protein structure & design |
|---|---|
| GitHub | Biohub/esm |
| First public | 2026-05-27 (source) |
| License | MIT |
| Pricing | Open source |
| Tags | #protein-language-model#structure-prediction#binder-design |
| Last checked | 2026-10-16 |
Specs
| Task | Structure prediction, design, embeddings |
|---|---|
| Modalities | Sequence → all-atom 3D structure, incl. complexes |
| MSA required | No |
| Open weights | Yes (Hugging Face) |
| GPU need | — |
| GitHub stars | — |
| Interface | — |
Specs come from each project's README, paper or official page · ESMFold2 & ESMC (Biohub) README · ESMFold2 & ESMC (Biohub) source 2 · ESMFold2 & ESMC (Biohub) README. “—” means we couldn't verify it.
Compare with…
Pick 1–3 other Protein structure & design tools to compare side by side with ESMFold2 & ESMC (Biohub).
Related
Structure prediction of proteins, nucleic acids, ligands and their complexes; free web server and code, weights on request for non-commercial use.
Protein structure & designFree (research)#structure#complexes
200M+ predicted protein structures from DeepMind and EMBL-EBI.
Protein structure & designOpen source#database#structure
Diffusion model for de novo protein backbone design and binder design.
Protein structure & designOpen source#design#diffusion